SP16: First-in-Class LRP1 Agonist
• POC data in STEMI
• Renal protection focused
• Phase 1b funded by NCI
• Extending to chronic disease

InhibRx acquired by Sanofi for $2.2B (2024) — same target| Feature | SP16 Platform | Plasma-Derived A1AT | Recombinant A1AT-Fc (InhibRx) |
|---|---|---|---|
| Potency | 300x higher than natural A1AT | Standard / compromised structure | Complex size & structure |
| Administration | Self-injected SC + oral/topical/mucosal (in dev.) | 1–2 hour clinic infusion | 1–2 hour infusion only |
| Administration Time | Instantaneous (subcutaneous injection) | Long (1–2 hours in clinic) | 1–2 hours |
| Supply / COGS | Unlimited synthetic supply, low cost | Scarce — extracted from plasma | High complexity; yield TBD |
| Safety | No immunosuppression risk | Risks from plasma-derived products | Immunogenicity (Fc portion) |
| IP Position | Patented through 2042 | Off patent | Patented |
| Mfg. Complexity | Low | High | High |
| A1AT Replacement Therapy | LRP1 Agonist (SP16) | |
|---|---|---|
| Route | Intravenous (weekly–monthly) | Oral (daily) — in development |
| LRP1-Binding | Indirect (NE:A1AT complex) | Direct — far more potent |
| Inflammation | ↓ (modest) | ↓↓↓ (highly potent) |
| Tissue Repair | ↑ (limited) | ↑↑↑ (strong regenerative effect) |

Our Story
Our story began with a team of scientists and visionaries looking to tackle one of healthcare’s greatest unmet needs: inflammatory diseases. When we recognized the potential for SERPIN proteins to mitigate these conditions, we committed to developing a first-in-class therapeutic to restore immune balance to harmful inflammatory environments.
Our therapeutic, now known as SP16, is currently undergoing pre-clinical and clinical trials for a broad span of orphan, chronic, and acute indications. We are currently collaborating with leaders across diverse fields of research to deliver our technology to the patients who need it most.
We believe that Serpin Pharma’s therapeutics are poised to shift the inflammatory disease landscape and provide lifelong solutions for a broad patient population.
| Project Title | Document Title | Action |
|---|---|---|
| Serpin Pharma | Serpin Pharma Corp PPP-Aug 23 2024 | |
| Serpin Pharma | Stock Restriction Agreement | |
| Serpin Pharma | Estée Lauder partnership Serpin Pharma |
| Program | Indication | Format | Stage | Partner |
|---|---|---|---|---|
| SP16 | Acute Kidney Injury (AKI) | Injectable Peptide | PHASE 2 | FAU Erlangen-Nürnberg |
| SP16 | Acute Myocardial Infarction (AMI) | Injectable Peptide | PHASE 2 | BIRD / Sheba Medical Center |
| SP16 | Cancer Pain — CIPN | Injectable (IV) | LICENSED | Dogwood Therapeutics + NCI |
| SP16 | Severe Skin Disease | Topical / Injectable | PHASE 2 READY | MetroDerm |
| RL-Series | CKD, Heart Failure | Oral Cyclic Peptide Analogs | PRECLINICAL | Open for Partnering |
| AT3 | Skincare / Anti-Aging | Natural Peptide | LICENSED | Estée Lauder Companies |
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